Bacterial Immunity and Host Defense

001 Abstract Microbes are the key players for deteriorating the host defense. They enter inside the host system, colonize the host cells, evade the host immunity and ultimately leads to tissue injury and ultimately disease. But the body cells are having strong immune system to combat with these aliens. There are two basic types of immune responses in body for bacterial degradation. Immune response for extracellular bacteria and immune response for intracellular invaders. The extracellular bacteria leads to cellular death via profound inflammation and by producing toxins. The toxins can be either exotoxins or endotoxins. The exotoxins are cytotoxic or interfere with cell function while the endotoxins which are LPS (component of cell wall) are potent activators of macrophages thereby associated with cellular damage.